If you set the Virtual Patient software to run with less than several square km of simulated environment or in low resolution mode, then you need to be sure and run the "defiant VP detector and shutdown routine" so as to avoid generating reams and reams of vitriolic rants mostly involving violations of human dignity. You can just filter those out of the data-set later if you want, but the d0m patient has a rather high defiance ratio, so better to shut the unhelpful instances down early and not waste the computation up-front.